منابع مشابه
Reverse engineering the (bya)8 barrel fold
The (bya)8 barrel is the most commonly occurring fold among protein catalysts. To lay a groundwork for engineering novel barrel proteins, we investigated the amino acid sequence restrictions at 182 structural positions of the prototypical (bya)8 barrel enzyme triosephosphate isomerase. Using combinatorial mutagenesis and functional selection, we find that turn sequences, a-helix capping and sto...
متن کاملEvolutionary markers in the (b/a)8-barrel fold
Enzymes with the (b/a)8-barrel fold are involved in the catalysis of a wide variety of biochemical reactions. The active sites of these enzymes are located on the C-terminal face of the central b-barrel. Conserved amino acid sequence, as well as secondary, tertiary and quaternary structure patterns are providing a rich body of data to support the premise of a common ancestry of many members of ...
متن کاملReverse Engineering is Reverse Forward Engineering
Reverse Engineering is focused on the challenging task of understanding legacy program code without having suitable documentation. Using a transformational forward engineering perspective, we gain the insight that much of this difficulty is caused by design decisions made during system development. Such decisions “hide” the program functionality and performance requirements in the final system ...
متن کاملReverse-engineering Reverse Mathematics
An important open problem in Reverse Mathematics ([16, 25]) is the reduction of the first-order strength of the base theory from IΣ1 to I∆0 + exp. The system ERNA, a version of Nonstandard Analysis based on the system I∆0 + exp, provides a partial solution to this problem. Indeed, Weak König’s lemma and many of its equivalent formulations from Reverse Mathematics can be ‘pushed down’ into ERNA,...
متن کاملReverse Reverse-Engineering
Reverse engineering a program constructs a high-level representation suitable for various software development purposes such as documentation or reengineering. Unfortunately however, there are no established guidelines to assess the adequacy of such a representation. We propose two such criteria, completeness and accuracy, and show how they can be determined during the course of reversing the r...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2001
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.041613598